HYAL1 and pachyonychia congenita: Sulfated hyaluronan (sHA), as an inhibitor of Hyal1, can inhibit PC cell growth, migration, and infiltration, downregulate Bcl-2 and p-Bad to induce apoptosis, and downregulate androgen receptor activation, NFkb activation, and VEGF expression via inhibiting the PI3K-AKT axis, which has been verified in animal models [23].