In conventionally housed IL-37tg mice with DSS induction, IL-37 receptors Il-18r1 and Il1rapl1 mRNA levels and additional downstream signaling pathway genes (Jun, Myd88, Sigirr, Smad3, Stat1, and Stat3) were expressed similarly as in control WT colitis mice (Figure S3D). This evidence concerns the gene SMAD3 and colitis.