IL1RAPL1 and colitis: In conventionally housed IL-37tg mice with DSS induction, IL-37 receptors Il-18r1 and Il1rapl1 mRNA levels and additional downstream signaling pathway genes (Jun, Myd88, Sigirr, Smad3, Stat1, and Stat3) were expressed similarly as in control WT colitis mice (Figure S3D).