In contrast, SPF IL-37tg mice demonstrated dramatically diminished inflammation after DSS induction, including effective improvements in body weight, disease activity index, and colonic inflammatory cytokines Il-1β and Il-6 mRNA expression compared to SPF WT mice (Figure S2A-C), consistent with previous reports showing the protective role of IL-37 in colitis mice under SPF conditions. This evidence concerns the gene IL37 and colitis.