In a secondary analysis of the FOURIER trial (an international, multicentre study which enrolled over 27,000 patients receiving statins for stable atherosclerotic disease and randomised them to receiving the PCSK9 inhibitor evolocumab versus a placebo), newly diagnosed or worsening AS, as well as aortic valve replacements, occurred in 63 patients. This evidence concerns the gene PCSK9 and aortic stenosis.