Known as tumor suppressors in certain cancers more than a decade ago 17-19, CBP/p300 have recently been demonstrated as important regulators of enhancer- and super-enhancer-mediated transcriptional activation of critical oncogenes 13, 16, 20, and small molecule CBP/p300 inhibitors are emerging as efficacious anticancer agents 13, 20, 21. This evidence concerns the gene CREBBP and cancer.