CCS1477 is the first p300/CBP inhibitor in phase I/IIa clinical trials in patients with advanced solid tumours, such as MYC over-expressing small cell lung cancer, radiation-induced breast sarcoma and metastatic castrate-resistant prostate cancer (ClinicalTrials.gov Identifier: NCT03568656) 110. Here, CREBBP is linked to Familial prostate cancer.