The structurally similar GNE-781 displays effective suppression of both CBP (IC50 = 0.94 nM) and p300 (IC50 = 1.2 nM), and strong efficacy in repressing the MYC oncogene (EC50 = 6.6 nM) in leukaemia cells 98 (Table 3). This evidence concerns the gene EP300 and leukemia.