Indeed, abundant YAP1 was detected in not only p53 negative but also p53 positive sarcomas (Figure S9), suggesting that other YAP1 regulators (e.g., components of the Hippo/LATS signaling pathway) may also contribute to the up-regulation of YAP1 expression and signaling in at least a subset of this disease. The gene discussed is TP53; the disease is sarcoma.