It is worth noting that, in contrast to an inhibitory role of CLP36 deficiency on the proliferation of p53 deficient sarcoma cells (Figures 3B, 4B and S1B), KO of CLP36 from p53 positive HT1080 fibrosarcoma cells reduced YAP1 expression (Figure S5B) but failed to inhibit cell proliferation (Figure S5B, right panel). Here, YAP1 is linked to fibrosarcoma.