Immunohistochemical staining showed that while sarcoma (Figure 5E) and thymic lymphoma (Figure 5F) tissues from CLP36+/+ p53-/- mice expressed abundant YAP1, its expression in the same tissues from CLP36+/- p53-/- mice, and to a greater extent that in the same tissues from CLP36-/- p53-/- mice, were reduced. This evidence concerns the gene TP53 and sarcoma.