Secondly, knockdown or KO of CLP36 from p53 deficient sarcoma cells was sufficient to inhibit sarcoma cell proliferation, focus formation, and anchorage-independent growth (Figures 3, 4 and S1), suggesting that the increase of CLP36 expression is critical for p53 deficiency-induced sarcoma growth. This evidence concerns the gene PDLIM1 and sarcoma.