The results showed that forced increase of YAP1 expression in CLP36 KO p53 deficient sarcoma cells completely restored cell proliferation (Figure 8B), focus formation (Figure 8C), and anchorage-independent growth (Figure 8D), indicating that the down-regulation of YAP1 expression is responsible for CLP36 deficiency-induced effects on these cellular processes. Here, TP53 is linked to sarcoma.