IFNG and neoplasm: Since UBR5 could enhance IFN-γ-induced PD-L1 expression to promote tumor growth, it was of interest to explore whether there are other IFN-γ responsive factors affected by UBR5, we performed transcriptome profiling with RNA-sequencing (RNA-seq) in 4T1/GFP and 4T1/Ubr5-/- cells treated with or without IFN-γ.