To define the role of DUSP2 in AKI pathogenesis, we generated RTEC-specific deletion of DUSP2 (Dusp2CKO) mice using a Cre-loxP recombination system involving Ggt1-Cre and Dusp2flox/flox (Dusp2fl/fl) mice (Figure 2A). This evidence concerns the gene DUSP2 and acute kidney injury.