XDH and hyperuricemia: The current drugs for hyperuricemia, such as allopurinol (an XO inhibitor), mainly inhibit the production or promote the excretion of UA (Borghi et al., 2020), but in view of some serious side effects of these drugs, such as hypersensitivity syndrome, gastrointestinal reactions, and kidney function damage, which have been limited to long-term use (Borghi et al., 2020; Liu et al., 2020).