In the present study, a positive correlation was observed in tumor SOX30 expression with accumulating OS in total CRC patients, and in the TNM stage II subgroup; more notably, multivariate Cox’s proportional hazards regression analysis presented that tumor SOX30 protein high expression was independently associated with favorable OS, which was partly consistent with previous studies (9, 11, 12). The gene discussed is SOX30; the disease is colorectal carcinoma.