In our study, we discovered several interesting results: (1) SOX30 protein and mRNA expressions were both reduced in CRC tumor tissue; (2) tumor SOX30 protein expression was negatively correlated with tumor size, LYN metastasis, T stage, N stage, and TNM stage; tumor SOX30 mRNA expression was negatively correlated with LYN metastasis, T stage, N stage, and TNM stage; (3) tumor SOX30 protein expression was positively correlated with accumulating OS, furthermore, tumor SOX30 protein high expression was independently associated with favorable OS. This evidence concerns the gene LYN and colorectal carcinoma.