In our study, we discovered several interesting results: (1) SOX30 protein and mRNA expressions were both reduced in CRC tumor tissue; (2) tumor SOX30 protein expression was negatively correlated with tumor size, LYN metastasis, T stage, N stage, and TNM stage; tumor SOX30 mRNA expression was negatively correlated with LYN metastasis, T stage, N stage, and TNM stage; (3) tumor SOX30 protein expression was positively correlated with accumulating OS, furthermore, tumor SOX30 protein high expression was independently associated with favorable OS. Here, SOX30 is linked to colorectal carcinoma.