Genotypic variants of the DNA repair gene, X-ray cross complementary group 3 (XRCC3) have been associated with a significantly higher cancer risk including AML (Bănescu et al., 2013), whereas polymorphisms of NAT2 an acetylator with epigenetic influences have been described as a modifier of tumorigenesis in various solid tumors (; Zhu et al., 2021). The gene discussed is NAT2; the disease is cancer.