Tumor cells also recruit platelets into the tumor microenvironment (TME), and platelets are activated by tumor cells to release the cytokines VEGF, CCL5, PDGF, TGFβ, PG, TPM3, LPA, PF4, PAF, and HGF, which promote the epithelial-mesenchymal transition of tumor cells (Mendoza-Almanza et al., 2020). Here, PF4 is linked to neoplasm.