However, different from the findings of Li et al., Jesus et al. verified that m6A level and METTL14 expression in pancreatic β-cells of diabetes patients is decreased, and down-regulation of m6A in pancreatic β-cells through METTL14 ablation impairs insulin secretion by decreasing pancreatic and duodenal homeobox 1 (PDX1) protein levels (De Jesus et al., 2019). The gene discussed is INS; the disease is diabetes mellitus.