Ma et al. found that FTO upregulates KLF5 expression through m6A methylation of KLF5 mRNA; KLF5 upregulates the expression of glycogen synthase kinase 3 and further promotes the development of aortic aneurysms by converting the contractile phenotype of VSMCs to a proliferative phenotype (Ma et al., 2020; Table 3 and Figure 2). This evidence concerns the gene KLF5 and aortic aneurysm.