Overexpression of FTO reduced plasma total cholesterol levels and ox-LDL deposition in macrophages, and increased cholesterol efflux from macrophages/foam cells by inhibiting the expression of peroxisome proliferator-activated receptor γ (PPARγ) and cluster of differentiation 36 (CD36), alleviating lipid metabolism disorder (Mo et al., 2017; Table 3 and Figure 2). The gene discussed is PPARG; the disease is Disorder of lipid metabolism.