FTO and type 2 diabetes mellitus: Similarly, FTO knockdown increases m6A methylation of SM22α; then the m6A RNA-binding protein IGF2BPs recognizes m6A-methylated SM22α mRNA and enhances its stability and expression, thus inhibiting the proliferation and migration of VSMCs in type 2 diabetes patients, while also improving intimal hyperplasia (Zhang et al., 2022; Table 1).