Using MAPT mutant iPSC lines derived from frontotemporal dementia (FTD) patients and corresponding isogenic controls, telencephalic organoids were generated which replicated the selective loss of glutamatergic neurons and early dysfunction of the autophagy-lysosomal pathway observed in 2D neuronal cultures and in vivo (Bowles et al., 2021). This evidence concerns the gene MAPT and frontotemporal dementia.