A small family of NF-kB (p50/p65)-regulated microRNAs (miRNAs) has been identified and partially characterized in Alzheimer's disease (AD) brain in the hippocampal CA1 and temporal lobe neocortical regions, and in reactive oxygen species (ROS)-, cytokine interleukin 1-beta (IL-1β)-, amyloid beta 42 (Aβ42) peptide- and/or lipopolysaccharide (LPS)-stressed human neuronal-glial (HNG) cells in primary co-culture. Here, RELA is linked to early-onset autosomal dominant Alzheimer disease.