In accordance with the expression and coefficient of candidate genes (Table 3), we developed an EMT-derived prognostic model for osteosarcoma, comprising RPS9, RPS23, EIF4A1, RPL12, RPL36, RPL37A, RPL34, EEF1B2, RPS8, RPS28, RPL10, RPS24, RPL35A, RPL11, RPL21, RPS27A, RPS12, and RPL13A. The gene discussed is RPL10; the disease is osteosarcoma.