This study conducted an EMT-derived prognostic model for osteosarcoma in the TARGET cohort, comprising EEF1B2, EIF4A1, RPL10, RPL11, RPL12, RPL13A, RPL21, RPL34, RPL35A, RPL36, RPL37A, RPS8, RPS9, RPS12, RPS23, RPS24, RPS27A, and RPS28. This evidence concerns the gene RPS23 and osteosarcoma.