In accordance with the expression and coefficient of candidate genes (Table 3), we developed an EMT-derived prognostic model for osteosarcoma, comprising RPS9, RPS23, EIF4A1, RPL12, RPL36, RPL37A, RPL34, EEF1B2, RPS8, RPS28, RPL10, RPS24, RPL35A, RPL11, RPL21, RPS27A, RPS12, and RPL13A. This evidence concerns the gene RPS8 and osteosarcoma.