This study conducted an EMT-derived prognostic model for osteosarcoma in the TARGET cohort, comprising EEF1B2, EIF4A1, RPL10, RPL11, RPL12, RPL13A, RPL21, RPL34, RPL35A, RPL36, RPL37A, RPS8, RPS9, RPS12, RPS23, RPS24, RPS27A, and RPS28. The gene discussed is RPL21; the disease is osteosarcoma.