Multivariate linear regression analyses and stepwise regression analysis were utilized to establish a prognostic gene model according to 13 PRGs (AIM2, CASP1, CASP5, CASP6, CASP8, CASP9, ELANE, GPX4, GSDMD, NLRP7, NOD2, PJVK, and PRKACA), which might predict the overall survival of CRC patients. This evidence concerns the gene GSDMD and colorectal carcinoma.