The formula of the modeling for colon and rectal cancer is risk_score = 0.116011 + 0.004995 × AIM2-0.000642 × CASP1 + 0.002337 × CASP5 + 0.000557 × CASP6-0.005383 × CASP8-0.007034 × CASP9-0.040302 × ELANE + 0.000154 × GPX4-0.000887 × GSDMD-0.116512 × NLRP7-0.004866 × NOD2 + 0.050655 × PJVK + 0.002196 × PRKACA. The gene discussed is GSDMD; the disease is rectal cancer.