Hanley et al. [32] have suggested Nox4 as a potentially promising CAF target based on Nox4 and αSMA IHC staining in stromal regions of human samples (head and neck squamous cell carcinoma, esophageal adenocarcinoma, and colon adenocarcinoma), as well as in vivo findings using TGFβ-activated skin fibroblasts. This evidence concerns the gene TGFB1 and head and neck squamous cell carcinoma.