A quantitation analysis reveals that GKT137831 treatment significantly reduced numbers of αSMA positive cells as compared to the WT group, which is in agreement with the tumor inhibition result shown in Fig. 2C. Similarly, we observed a significant decrease in the number of activated fibroblasts in the GKT137831 treated 4T1-tumor stroma (Fig. 2H and I). Here, ACTA1 is linked to neoplasm.