Cascades of signaling activate the channels and macropores for ATP penetration and further provoke different manners of cancer cell death including apoptosis mediated by pannexin-1 (PANX-1) channels, necroptosis induced by mixed-lineage kinase domain-like pseudokinase (MLKL) pores, and pyroptosis activated by Gasdermin D (GSDMD) and/or Gasdermin E (GSDME) pores [55]. Here, GSDMD is linked to cancer.