After that, CTLs can proliferate and expand to enhance their antitumor cytotoxicity by increase the secretion of IFN-γ, perforin-1, and granzyme B and/or with a combination of Fas ligand (FasL) with Fas interaction when infiltrate the irradiated tumor site as well as the abscopal sites to induce ICD [62, 65] (Fig. 2A). Here, FASLG is linked to neoplasm.