Next, qRT–PCR on two TMZ-sensitive (U251: IC50 = 497.9 μM; LN229: IC50 = 503.0 μM) and TMZ-resistant (U118MG: IC50 = 1100.0 μM; U87MG: IC50 = 814.7 μM) GBM cell lines verified that PDIA3P1 was upregulated in TMZ-resistant cell lines (Fig. S1C). The gene discussed is PDIA3P1; the disease is glioblastoma.