We speculated that the failure to correlate the expression of STAT3 with the pathological grading in FISSs may be due to the soft tissue sarcoma grading system used in this and previous studies [20, 43–45] was inappropriate for FISS since most of the cases were graded as 2–3 due to the high score allocated for necrosis. This evidence concerns the gene STAT3 and soft tissue sarcoma.