The high expression rates of STAT3 and phospho-STAT3 (Tyr705) in FISSs and the in vitro reduction in proliferation and tumor migration in FISS primary cells by the STAT3 phosphorylation (Tyr705) inhibitor in the present study suggest that the STAT3 may play an important role in the tumorigenesis of FISS and could be a potential therapeutic target for FISSs. This evidence concerns the gene STAT3 and neoplasm.