Nuclear phospho-STAT3 (Tyr705) expression with score 1, 2, and 3 were noted in 28.9% (13/45), 17.8% (8/45), and 6.7% (3/45) FISS cases, repsectively, According to Pearson’s correlation coefficient (r), the IHC scores of STAT3 and phospho-STAT3 (Tyr705) in FISSs were not significantly correlated with tumor grading, necrosis, and mitosis (P > 0.05). This evidence concerns the gene STAT3 and neoplasm.