STAT3 and neoplasm: Both pathways interfere with tumor cells and induce the activation of several key transcription factors in tumor cells leading to tumor-associated inflammation, including nuclear factor-κB (NF-κB), signal transducer and activator of transcription 3 (STAT3), and hypoxia-inducible factor 1 α, impacting any stage of tumorigenesis, such as initiation, promotion, progression, and metastasis [17].