While the IHC scores of both STAT3 and phospho-STAT3 (Tyr705) in FISSs were not significantly correlated with tumor grading (P > 0.05), the high expression of both STAT3 and phospho-STAT3 (Tyr705) in FISSs suggests that disruption of the Janus kinase (JAK)-STAT3 signaling pathway may be a potential therapy for FISSs. This evidence concerns the gene STAT3 and neoplasm.