In particular, MAGE-A3 is over-expressed in multiple tumor types including melanoma [35] and lung cancer [36] and its presence has been associated with worse prognosis in colorectal cancer [37], cutaneous squamous cell carcinoma [38], and undifferentiated pleomorphic sarcoma/myxofibrosarcoma [39]. The gene discussed is MAGEA3; the disease is cutaneous squamous cell carcinoma.