Although there has been research showing an elevation of IL-18 in aqueous humor of patients with uveitis [215, 217], and an increased susceptibility to uveitis in patients with Behçet’s disease along with IL-18 promoter polymorphisms [218], it is a pity that strategies targeting IL-18 signaling have not drawn much attention from scientists focusing on uveitis. The gene discussed is IL18; the disease is Behcet disease.