Although there is plenty of research in the field of AMD proving that NLRP3 inflammasome activation will lead to GSDMD-mediated pyroptosis in recent years [10, 124, 126, 127, 134, 145], most of the current research mainly focuses on the process of NLRP3 activation and lacks evidence revealing whether the RPE cell death form is indeed pyroptosis. Here, GSDMD is linked to age-related macular degeneration.