The homologous recombination pathway plays a vital role in DNA repair and involves many genes [6], including BRCA (BRCA1/2), ATM, CHEK2, etc. Accumulated evidence has revealed the value of homologous recombination deficiency (HRD) in PCa, representing a high risk of PCa carcinogenesis and aggressiveness. The gene discussed is BRCA1; the disease is posterior cortical atrophy.