Based on previous findings reduced IGF2 contents in infertile female other than obesity was noticed (e.g., oocytes from patients with ovarian hyperstimulation syndrome and polycystic ovarian syndrome), perhaps adding IGF2 to culturing systems may have the potential to improve the revenue of embryos with better quality from these additional populations of women, which may also exert a positive impact on implantation as well as pregnancy rate. This evidence concerns the gene IGF2 and ovarian hyperstimulation syndrome.