SMAD3 and colorectal carcinoma: For example, Chen et al. demonstrated that METTL3 can induce circ1662 formation by installing m6A modifications in its flanking reverse complementary sequences via MeRIP assay, thus promoting epithelial-mesenchymal transition (EMT) and accelerating lung metastases of CRC via the YAP1-mothers against decapentaplegic homolog 3 (SMAD3) axis (Chen et al. 2021).