ALKBH5 and cancer: For example, one research has revealed that ALKBH5-mediated alterations in m6A density can regulate the splicing and expression of mRNAs with potential roles in controlling tumor growth, thus suggesting that ALKBH5, the m6A demethylase, can be a potential therapeutic target for cancer treatment alone or in combination with immune checkpoint blockade (ICB) (Li et al. 2020).