However, there were few experimental studies demonstrating whether these 19 ARGs were collectively associated with sensitivity to the five identified chemo drugs except studies that docetaxel could markedly suppress the expression of VEGFA (Zhu et al. 2014), and the VEGFA-VEGFR2 signaling pathway could be regulated when receiving the chemo drugs of cisplatin or paclitaxel in prostate cancer (Yun et al. 2021). This evidence concerns the gene SERPINA2 and prostate carcinoma.