In order to elucidate the molecular mechanism underlying the modulatory activity of KLF5 on the function of NPC cells, we examined the possible upstream miRNA regulators of KLF5 using four different miRNA target-predicting tools, and we found miR-143-3p, miR-148-3p, miR-145-5p, miR-153-3p, miR-21-5p and miR-214-5p may target to 3'-UTR of KLF5 mRNA. This evidence concerns the gene KLF5 and nasopharyngeal carcinoma.