In univariate analysis, disease duration, other types of allergic disease, number of involved organs ≥ 3, lymph node involvement, salivary gland involvement, thyroid gland involvement, lung involvement, biliary system involvement, gallbladder involvement, salivary gland involvement, lacrimal gland involvement, parotid gland involvement, higher level of serum IgG4, higher level of serum IgE, higher level of ESR, eosinophilia and hypocomplementemia were associated with higher rate of IgG4-RD complicated with AR/CRS (Table 3). Here, IGHE is linked to congenital rubella syndrome.