CCN2 and diabetes mellitus: In support of this, up-stream (CTGF [UniProtKB:O18739]) and CD62 [UniProtKB:P98107])99,100 (Table S5) and down-stream proteins (FABP4 [UniProtKB:P48035])101 (Table S5) involved in angiogenesis and proliferation were down-regulated by simulated diabetes.