Expression of OAS1-p46 (created by rs10774671-G allele) was higher than that of other OAS1 isoforms in all datasets tested: adjacent normal tissues from The Cancer Genome Atlas (TCGA) (Extended Data Fig. 7), nasal epithelial cells infected with rhinovirus (Extended Data Fig. 8a), pulmonary alveolar type 1 cell-based organoids infected with SARS-CoV-2 (Extended Data Fig. 8b) and peripheral blood mononuclear cells (PBMCs) from COVID-19 patients (Extended Data Fig. 8c). This evidence concerns the gene OAS1 and COVID-19.