The overall CH loci at 5p15.33-TERT (signals with lead variants rs2853677, rs13156167 and rs7705526), 3q25.33-SMC4, 6q21-CD164 and 11q22.3-ATM were also genome-wide significant for DNMT3A-CH. The gene discussed is SMC4; the disease is cyclic hematopoiesis.