SMC4 and cyclic hematopoiesis: When comparing 4,049 individuals with large or 6,154 individuals with small clones against the 173,918 controls without CH, we found that the overall CH loci at 5p15.33-TERT and 3q25.33-SMC4 were associated at genome-wide significance with large clone CH (Fig. 4d and Supplementary Table 20), while 5p15.33-TERT and 6q21-CD164 were associated with small clone CH.