Focusing on 5,185 individuals with DNMT3A and 2,041 with TET2 mutations and 173,918 controls (individuals of European ancestry without CH), we identified eight and three genome-wide significant loci associated with DNMT3A- and TET2-mutant CH, respectively (Fig. 4b,c and Supplementary Tables 18 and 19). This evidence concerns the gene TET2 and cyclic hematopoiesis.