Genetically predicted longer LTL was associated with increased overall CH risk (OR = 1.56, 95% CI: 1.25–1.93, P = 5.7 × 10−5), and with DNMT3A-, TET2-, and large and small clone CH (Fig. 6b and Supplementary Table 36). This evidence concerns the gene DNMT3A and cyclic hematopoiesis.