DNMT3A and cyclic hematopoiesis: However, we did uncover an association between genetic liability to overall CH or DNMT3A-CH and atrial fibrillation76 risk (OR = 1.09, 95% CI: 1.04–1.15, P = 4.9 × 10−4 for overall CH with the GWS instrument; Supplementary Table 39).