Examining heterogeneity of associations across the five CH traits using forest plots (Extended Data Fig. 5a–e and Supplementary Tables 16 and 18–21) revealed that in addition to 14q32.13-TCL1A, the lead alleles at 6q21-CD164 also had opposite effects on DNMT3A- versus TET2-CH. The gene discussed is DNMT3A; the disease is cyclic hematopoiesis.