Interestingly, the age-related rise in CH prevalence differed between driver genes (Fig. 1b and Extended Data Fig. 2a–c), for example, DNMT3A prevalence rose earlier in life compared with SF3B1 and SRSF2, consistent with what we now know about the lifelong behavior of these CH subtypes20. Here, SF3B1 is linked to cyclic hematopoiesis.