Whereas the induction of Arg1 and Fizz1 by IL-4 was blunted, as expected, by hyperglycemia, the effect of PRMT2-deficiency in BMDMs is similar to that of hyperglycemia in that the levels of Arg1 and Fizz1 were lower than the corresponding values for the sufficient cells (Fig. 4A,B). Here, RETNLB is linked to Hyperglycemia.