LRP1 and neoplasm: The previous findings by many laboratories on LRP-1’s support for tumour cell migration, invasion and tumour formation7,8,11–14 led us to investigate the role of LRP-1 in maintaining the constitutive motility and the possible mechanism in 231 cells, as schematically depicted in Fig. 2A. We used lentiviral infection-mediated shRNA delivery to downregulate LRP-1.