NFKB1 and neoplasm: Other anti-cancer mechanisms for aspirin have included inhibiting cyclooxygenase4, activating AMPK, mTOR, STAT3, and NF-κB pathways5, decreasing reactive oxygen species (ROS)6, inducing autophagy7, and changing tumor microenvironment8. Moreover, aspirin could meditate its anti-cancerous properties by changing the expression of non-coding RNAs, such as microRNAs (miRs)9.