In that analysis, 6 gene-traits pairs are driven by gene expression in NK cells specifically; CD226 expression modifies systemic lupus erythematosus and primary biliary cirrhosis risk, TMEM163 expression modifies primary biliary cirrhosis risk, CALHM6 expression modifies ulcerative colitis risk, and both ZMIZ1 and OSM modify Crohn’s disease risk. This evidence concerns the gene TMEM163 and primary biliary cholangitis.