Whilst the effect of MC1R/αMSH signalling in NK cells is undefined, NK cell dysfunction, as part of broader immunodeficiency, is well-characterised as part of syndromic disorders of hypopigmentation, e.g. Chediak-Higashi, Hermansky-Pudlak and Griscelli syndromes40. The gene discussed is MC1R; the disease is Immunodeficiency.