TM4SF1 and esophageal squamous cell carcinoma: Considering a growing body of evidence for the TEMs formed by TM4SF1 and other proteins during migration, and also our MS analysis identified a series of TM4SF1-interacting integrins, it is reasonable to speculate that TM4SF1 may be associated with laminin receptor integrins which facilitate cell adhesion and motility by activating downstream signal pathways in ESCC cells.