However, it is well known that laminin-5 (also named laminin-332), as the preferred ligand of integrin α6β4 and α6β1 [30, 31], can promote the invasion of ESCC cells [32]; further investigations are needed to identify the exact laminin isoform involved in TM4SF1/integrin α6-mediated metastasis and the mechanistic roles of TM4SF1-containing (TEMs) in ESCC in more detail. The gene discussed is TM4SF1; the disease is esophageal squamous cell carcinoma.