TM4SF1 and esophageal squamous cell carcinoma: Consistent with the importance of TM4SF1 in ESCC cells we observed, our TMA analysis indicated that the upregulated TM4SF1 was closely associated with worse clinical outcomes and shorter survival in ESCC patients, suggesting that TM4SF1 may serve as a potential prognostic biomarker for predicting metastasis and a novel therapeutic target in ESCC.