Notably, the Kaplan-Meier survival curves also showed that the overall survival of patient classified as TM4SF1high/integrin α6high or TM4SF1high/pFAKhigh group had a poorer outcome than TM4SF1low/integrin α6high or TM4SF1low/pFAKhigh group, respectively, further suggesting the importance of TM4SF1/integrin α6/FAK axis in ESCC (Fig. 7F, G). Here, PTK2 is linked to esophageal squamous cell carcinoma.