The Dp3Tyb model contains an additional copy of 38 genes, including Dyrk1a, a kinase that phosphorylates APP (Ryoo et al., 2008), increasing the abundance of the protein in vivo, contributing to raised soluble Aβ abundance in the Ts65Dn mouse model of DS (Garcia-Cerro et al., 2017). Here, APP is linked to Dravet syndrome.