Most importantly, of particular interest with regard to the apoptotic process is the downregulation in both cell lines of BST2 (also known as CD317), as knockdown of this factor in serum-deprived tumor cells has been shown to impair mitochondria function and subsequently promote the release and nuclear translocation of apoptosis-inducing factor 1 (AIF1) (51). The gene discussed is BST2; the disease is neoplasm.