Supporting this, targeting the autophagy pathway using Rapamycin, a known inhibitor for mammalian target of rapamycin (mTOR) pathway, decreased the expression of fibrosis markers (alpha smooth muscle actin and fibronectin) in human fibroblast cell lines and lung hydroxyproline content in bleomycin model of lung fibrosis.15 The gene discussed is MTOR; the disease is pulmonary fibrosis.