We then established an AD murine model using AhR-inhibited mice; we observed that AD mice given CH-223191 showed no recovery of ear thickness, TEWL, and dermatitis scores, scratching behavior, or total IgE levels after treatment with mBD-14 (AD mice + CH + mBD-14), although these parameters were recovered in mBD-14–treated AD mice in the absence of CH-223191 (AD mice + mBD-14; Figure 7, A and B, and Supplemental Figure 8E). Here, C4B is linked to Alzheimer disease.