p62 acts as a selective autophagy adaptor and enhances inflammation in skin conditions, including AD and psoriasis, which are characterized by defects in the epidermal barrier and keratinocyte differentiation, through signaling of nuclear factor κ light chain enhancer of activated B cells (NF-κB) and mechanistic target of rapamycin (mTOR) (6). The gene discussed is MTOR; the disease is Alzheimer disease.