Likewise, mBD-14 significantly increased the expression of Cldn1 and Tjp1 (ZO-1) and decreased the expression of Il4, Il13, Il33, and Tslp in K14Cre AD mice; however, these therapeutic effects were not observed in K14Cre Atg7fl/fl AD mice (Figure 6C). Here, CLDN1 is linked to Alzheimer disease.