While mBD-14 significantly decreased the ear thickness, TEWL, dermatitis scores, scratching behavior, and total IgE of K14Cre AD mice, this peptide failed to improve these AD characteristics in autophagy-deficient K14Cre Atg7fl/fl AD mice (Figure 6, A and B, and Supplemental Figure 8A). Here, IGHE is linked to skin disorder.