Genetic studies have implicated the ARL15 gene locus in rheumatoid arthritis and multiple metabolic diseases (Corre et al., 2018; Danila et al., 2013; Glessner et al., 2010; Li et al., 2014; Negi et al., 2013; Mahajan et al., 2014; Richards et al., 2009; Ried et al., 2016; Sun et al., 2015; Willer et al., 2013). This evidence concerns the gene ARL15 and Other metabolic disease.