AGT and endothelial dysfunction: Stimulation of angiotensin II type 2 and angiotensin II type 4 receptors leads to reduced oxidative stress, neuroinflammation, and endothelial dysfunction, and improved cerebral hypoperfusion, potentially leading to memory-enhancing effects.7,8,9 In contrast, by inhibiting the conversion of angiotensin I to angiotensin II, ACEIs lower circulating angiotensin II and thereby reduce stimulation of angiotensin II type 1, as well as angiotensin II type 2 and angiotensin II type 4 receptor activity.