COX-2 triggers overproduction of prostaglandin E2 (PGE-2) and thromboxane B2 (TXB2), which are two of the vital inflammatory mediators in colitis-associated colonic cell damage, inflammation, and edema, in addition to TXB2-induced vasoconstriction, platelet aggregation, and thrombosis (Dong et al. 2003) Previous studies confirmed their role in UC pathogenesis in animal models of colitis (Auwerda et al. 2001, Medina 2001, Appleyard et al. 2002). Here, PTGS2 is linked to colitis.