ORC4 and Werner syndrome: Examples of these syndromes include Cockayne syndrome (caused by mutations in the ERCC6 and ERCC8 genes), Ataxia‐ Telangiectasia (ATM), AT‐like disorder (Mre11), Bloom syndrome (BLM), Seckel syndrome (DNA2), Fanconi Anemia (which is characterized by defects in ICL repair), Werner syndrome (WRN), Meir‐Gorlin syndrome (ORC1, ORC4, ORC6, CDT1, CDC6) and Xeroderma Pigmentosa (XPA‐G, XPV) [3, 189].