HMGB1 and chronic myelogenous leukemia, BCR-ABL1 positive: In the corresponding RA tissue, CML levels were unaltered, but HMGB1 levels showed a similar regulation to LA HMGB1 with significantly increased HMGB1 levels and NFkB activation solely in the SHRob group and with normalization of both parameters after RDN (Supplementary Table 1; Supplementary Fig. 4a–c).