Adès et al. reported that peripheral WBC > 13 × 109/L was associated with worse OS in CMML patients treated with AZA [36].In a large cohort of retrospective multicenter study including 280 CMML patients from Latin American, González et al. revealed that Hb ≥ 8- < 10 g/dL, Hb < 8 g/dL, poor karyotypes, WHO 2016-CMML-1, and CMML-2 were independent adverse clinical factors associated with poor survival of CMML [11]. Here, GSTM1 is linked to chronic myelomonocytic leukemia.