Chi‐square analysis indicated that NPS had a statistically significant association with sex, age, BMI, CEA, CA19‐9, Borrmann type, tumor diameter, tumor location, pTNM stage, venous invasion, nerve infiltration, lymph node metastasis rate, vascular invasion, PNI, and SIS (P = 0.008, P = 0.002, P = 0.003, P = 0.009, P = 0.001, P < 0.001, P < 0.001, P = 0.041, P < 0.001, P = 0.001, P < 0.001, P < 0.001, P < 0.001, P < 0.001, and P < 0.001) (Table 3). This evidence concerns the gene CEACAM5 and neoplasm.