In this line, several proteins have been identified to interact with NIS and participate in thyroid cancer, including leukemia-associated RhoGEF (LARG),19 pituitary tumor transforming gene binding factor,20,21 ADP ribosylation factor 4 (ARF4),22 and valosin-containing protein.22 This evidence concerns the gene SLC5A5 and thyroid gland carcinoma.