In this line, several proteins have been identified to interact with NIS and participate in thyroid cancer, including leukemia-associated RhoGEF (LARG),19 pituitary tumor transforming gene binding factor,20,21 ADP ribosylation factor 4 (ARF4),22 and valosin-containing protein.22 The gene discussed is ARF4; the disease is thyroid gland carcinoma.