Elevated ATX levels were observed in patients with different etiological liver diseases that correlated with disease severity including nonalcoholic fatty liver disease (NAFLD) (Nakagawa et al, 2011; Kondo et al, 2014; Yamazaki et al, 2017; Ando et al, 2018; Fujimori et al, 2018; Joshita et al, 2018). The gene discussed is ENPP2; the disease is liver disorder.