The ATX/LPA signaling axis has previously shown to be involved with the initiation and progression of liver diseases (Nakagawa et al, 2011; Kondo et al, 2014; Yamazaki et al, 2017; Ando et al, 2018; Fujimori et al, 2018; Joshita et al, 2018). This evidence concerns the gene LPA and liver disorder.