ENPP2 and metabolic dysfunction-associated steatohepatitis: To mimic NASH phenotype, human hepatoblastoma cell line, HepG2 cells, were exposed to pathophysiological relevant concentrations of palmitic acid to mimic excessive influx of fatty acids into hepatocytes (Joshi‐Barve et al, 2007) and found that ATX inhibition by Cpd17 significantly reduced lipid accumulation in hepatocytes compared with PF8380 as assessed using Oil‐red‐O staining (Fig 3A).