FGF8 and cancer: We next performed ORA of all upregulated genes across all four time points and found pathways related to cancer, PI3K-Akt signaling and MAPK signaling within the top ten entries to be enriched, whereas HSV1 infection and olfactory transduction pathways were depleted (Fig. S4), which was similar to the results shown after 2 days of FGF8 exposure.